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<p>Hi Maxime,</p>
<p><br>
</p>
<p>Just for precision, the TOF resolution has to be set by the user.
It is the TOF range which is automatically converted from GATE
files (from the coincidence window value, and only if not set by
the user). <br>
</p>
<p><br>
</p>
<p>You are right about the warnings though.</p>
<p><br>
</p>
<p>Best,<br>
Thibaut<br>
</p>
<p><br>
</p>
<div class="moz-cite-prefix">On 26/04/2021 17:09, Maxime Toussaint
wrote:<br>
</div>
<blockquote type="cite"
cite="mid:YQBPR0101MB14433CBCAAA8EF0A03E859FAF6429@YQBPR0101MB1443.CANPRD01.PROD.OUTLOOK.COM">
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255, 255);">
Greetings,</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
Oh, you included optical photons in your simulation. I am less
familliar in how GATE deal with that case.</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
In a basic simulation, without optical photons, the time
registered for Singles/Coincidences is directly the time of
interaction of a gamma with a "CrystalSD". It does not
correspond to reality but it is the best GATE can do when it
does not emulate a photodetector and it is good enough, as you
said, with TOF resolution >100 ps*. </div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
I believe that some users of GATE + CASToR might not have your
insight about the correct manipulation of ultra-fast timing
resolution (i.e. adapting GATE timing). As such, it might be
usefull to add a comment on that part in the documentation of
GATE-to-CASToR model conversion tool since CASToR extract TOF
resolution from GATE mac file. It might even be usefull to add a
warning in the documentation about the TOF kernel with
ultra-fast timing since it can become non-Gaussian in those
cases. </div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
Best,</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
Maxime Toussaint</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
<br>
</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0); background-color: rgb(255,
255, 255);">
* For typical detectors</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0);">
<br>
</div>
<hr tabindex="-1" style="display:inline-block; width:98%">
<div id="divRplyFwdMsg" dir="ltr"><font style="font-size: 11pt;"
face="Calibri, sans-serif" color="#000000"><b>De :</b>
Castor-users
<a class="moz-txt-link-rfc2396E" href="mailto:castor-users-bounces@lists.castor-project.org"><castor-users-bounces@lists.castor-project.org></a> de la
part de COMTAT Claude <a class="moz-txt-link-rfc2396E" href="mailto:claude.comtat@cea.fr"><claude.comtat@cea.fr></a><br>
<b>Envoyé :</b> 26 avril 2021 05:30<br>
<b>À :</b> <a class="moz-txt-link-abbreviated" href="mailto:castor-users@lists.castor-project.org">castor-users@lists.castor-project.org</a>
<a class="moz-txt-link-rfc2396E" href="mailto:castor-users@lists.castor-project.org"><castor-users@lists.castor-project.org></a><br>
<b>Objet :</b> Re: [Castor-users] CASToR TOF reconstruction</font>
<div> </div>
</div>
<div lang="FR">
<div class="x_WordSection1">
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New Roman",
serif;margin: 0cm 0cm 0.0001pt; font-size: 12pt;
font-family: "Times New Roman", serif;">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">It was
vGATE 9.0, and we analysed the root output (time
difference). The result as such is not surprizing. As far
as I understood, the time is set according to the very
last interaction resulting from the detection of the
single photon in the detector. It includes obviously the
effect of variable depth of interaction. We measured a
value of 72 ps FWHM. When we added a time resolution of X
[ps]
(/gate/digitizer/Singles/timeResolution/setTimeResolution
X), the measured coincidence time resolution fitted nicely
with SQRT(X^2 + X^2 + 72^2).</span></p>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New Roman",
serif;margin: 0cm 0cm 0.0001pt; font-size: 12pt;
font-family: "Times New Roman", serif;">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Now, if
you wish to simulate ultra-fast timing resolution (<
100 ps), you need to modify how the time is set in GATE
(for example, consider the detection of the first
photoelectron).</span></p>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New Roman",
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<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Best,</span></p>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
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<b><span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Claude
COMTAT</span></b></p>
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<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Laboratoire
d’Imagerie Biomédicale Multimodale Paris Saclay</span></p>
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<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Université
Paris-Saclay, CEA, CNRS, Inserm</span></p>
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<span style="font-size: 11pt; font-family: Calibri,
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Hospitalier Frédéric Joliot</span></p>
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<span style="font-size: 11pt; font-family: Calibri,
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Orsay, France</span></p>
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padding:3.0pt 0cm 0cm 0cm">
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
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serif;margin-left:35.4pt">
<b><span style="font-size:11.0pt;
font-family:"Calibri",sans-serif"
lang="EN-GB">De :</span></b><span
style="font-size:11.0pt;
font-family:"Calibri",sans-serif"
lang="EN-GB"> Castor-users
<a class="moz-txt-link-rfc2396E" href="mailto:castor-users-bounces@lists.castor-project.org"><castor-users-bounces@lists.castor-project.org></a>
<b>De la part de</b> Maxime Toussaint<br>
<b>Envoyé :</b> dimanche 25 avril 2021 00:03<br>
<b>À :</b> <a class="moz-txt-link-abbreviated" href="mailto:castor-users@lists.castor-project.org">castor-users@lists.castor-project.org</a><br>
<b>Objet :</b> Re: [Castor-users] CASToR TOF
reconstruction</span></p>
</div>
</div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
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serif;margin: 0cm 0cm 0.0001pt; font-size: 12pt;
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serif;margin-left:35.4pt">
<span lang="EN-GB"> </span></p>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Greetings,</span></p>
</div>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"> </span></p>
</div>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">On which version of GATE and which
type of data file (root, binary, ascci) did you observe
this behavior? In the past, I tested a range of TOF
resolution with Gate v8.0 using binary output and I did
not observe this behavior.</span></p>
</div>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"> </span></p>
</div>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Are you peharps referring to the
effect of depth of interaction on coincidence timing
resolution? F<span style="background: white;">or typical
detectors, the effect on timing resolution </span>would
indeed be less than 100 ps.</span></p>
</div>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"> </span></p>
</div>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Best,</span></p>
</div>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt
35.4pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Maxime Toussaint</span></p>
</div>
<div>
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serif;margin: 0cm 0cm 0.0001pt; font-size: 12pt;
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serif;margin-left:35.4pt">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"> </span></p>
</div>
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serif;margin-left:35.4pt; text-align:center" align="center">
<span lang="EN-GB">
<hr width="98%" size="5" align="center">
</span></div>
<div id="x_divRplyFwdMsg">
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
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serif;margin-left:35.4pt">
<b><span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: black;" lang="EN-GB">De :</span></b><span
style="font-size: 11pt; font-family: Calibri,
sans-serif; color: black;" lang="EN-GB"> Castor-users
<<a
href="mailto:castor-users-bounces@lists.castor-project.org"
moz-do-not-send="true">castor-users-bounces@lists.castor-project.org</a>>
de la part de COMTAT Claude <<a
href="mailto:claude.comtat@cea.fr"
moz-do-not-send="true">claude.comtat@cea.fr</a>><br>
<b>Envoyé :</b> 24 avril 2021 10:05<br>
<b>À :</b> <a
href="mailto:castor-users@lists.castor-project.org"
moz-do-not-send="true">castor-users@lists.castor-project.org</a>
<<a
href="mailto:castor-users@lists.castor-project.org"
moz-do-not-send="true">castor-users@lists.castor-project.org</a>><br>
<b>Objet :</b> Re: [Castor-users] CASToR TOF
reconstruction</span><span lang="EN-GB">
</span></p>
<div>
<p class="x_MsoNormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
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serif;margin-left:35.4pt">
<span lang="EN-GB"> </span></p>
</div>
</div>
<div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
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Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
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serif;margin-left:35.4pt">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Hello,</span><span
lang="EN-GB"></span></p>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
12pt; font-family: "Times New Roman",
serif;margin-left:35.4pt">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB"> </span><span
lang="EN-GB"></span></p>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
12pt; font-family: "Times New Roman",
serif;margin-left:35.4pt">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">just
a comment: for a GATE simulation, the effective
coincidence resolution is not just SQRT(2*<i>X</i>^2).
If you set
<i>X</i> to zero in GATE and draw the ToF histogram
for a perfectly centred point source, you will see
that the width of the distribution is not zero. There
is an intrinsic coincidence time resolution
<i>E</i> in GATE, related to the way the time
information is stored. So, the effective coincidence
resolution is SQRT(2*<i>X</i>^2 +
<i>E</i>^2). Now, <i>E</i> is typically less than 100
ps. So, depending on X, it can be negligible.
</span><span lang="EN-GB"></span></p>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
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serif;margin-left:35.4pt">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB"> </span><span
lang="EN-GB"></span></p>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
12pt; font-family: "Times New Roman",
serif;margin-left:35.4pt">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Best,</span><span
lang="EN-GB"></span></p>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
12pt; font-family: "Times New Roman",
serif;margin-left:35.4pt">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB"> </span><span
lang="EN-GB"></span></p>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
12pt; font-family: "Times New Roman",
serif;margin-left:35.4pt">
<span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: rgb(31, 73, 125);" lang="EN-GB">Claude</span><span
lang="EN-GB"></span></p>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
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<p class="x_xmsonormal" style="margin: 0cm 0cm
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<b><span style="font-size:11.0pt;
font-family:"Calibri",sans-serif"
lang="EN-GB">De :</span></b><span
style="font-size:11.0pt;
font-family:"Calibri",sans-serif"
lang="EN-GB"> Castor-users <<a
href="mailto:castor-users-bounces@lists.castor-project.org"
moz-do-not-send="true">castor-users-bounces@lists.castor-project.org</a>>
<b>De la part de</b> Maxime Toussaint<br>
<b>Envoyé :</b> vendredi 23 avril 2021 20:05<br>
<b>À :</b> <a
href="mailto:castor-users@lists.castor-project.org"
moz-do-not-send="true">castor-users@lists.castor-project.org</a><br>
<b>Objet :</b> Re: [Castor-users] CASToR TOF
reconstruction</span><span lang="EN-GB"></span></p>
</div>
</div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt; font-size:
12pt; font-family: "Times New Roman",
serif;margin-left:70.8pt">
<span lang="EN-GB"> </span></p>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Greetings,</span><span
lang="EN-GB"></span></p>
</div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"><br>
The profiles remind me of a nice paper that studied
the consequences of over/under estimation of the TOF
kernel. Since you use GATE, is it possible that you
have made a slight error in setting the TOF
resolution? The command in GATE
"/gate/digitizer/Singles/timeResolution/setTimeResolution
X" defines the <b>single</b> resolution as X. As
such, the <b>coincidence</b> resolution is sqrt(2)
* X.
</span><span lang="EN-GB"></span></p>
</div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"> </span><span lang="EN-GB"></span></p>
</div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Note: My memory tells me that
CASTOR extract the coincidence TOF resolution
directly from the .mac, so this should not happen.
However, you "set it by hand", which makes it a
possibility.</span><span lang="EN-GB"></span></p>
</div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"> </span><span lang="EN-GB"></span></p>
</div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Bests,</span><span lang="EN-GB"></span></p>
</div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB">Maxime Toussaint</span><span
lang="EN-GB"></span></p>
</div>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt
70.8pt; font-size: 12pt; font-family: "Times New
Roman", serif; background: white;">
<span style="font-family: Calibri, sans-serif; color:
black;" lang="EN-GB"> </span><span lang="EN-GB"></span></p>
</div>
<div style="margin-left:35.4pt">
<div class="x_MsoNormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin-left:35.4pt;
text-align:center" align="center">
<span lang="EN-GB">
<hr width="98%" size="5" align="center">
</span></div>
</div>
<div id="x_x_divRplyFwdMsg">
<p class="x_xmsonormal" style="margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-left:70.8pt">
<b><span style="font-size: 11pt; font-family: Calibri,
sans-serif; color: black;" lang="EN-GB">De :</span></b><span
style="font-size: 11pt; font-family: Calibri,
sans-serif; color: black;" lang="EN-GB">
Castor-users <<a
href="mailto:castor-users-bounces@lists.castor-project.org"
moz-do-not-send="true">castor-users-bounces@lists.castor-project.org</a>>
de la part de Philip Kalaitzidis <<a
href="mailto:kalaitzidis.philip@gmail.com"
moz-do-not-send="true">kalaitzidis.philip@gmail.com</a>><br>
<b>Envoyé :</b> 23 avril 2021 12:54<br>
<b>À :</b> <a
href="mailto:castor-users@lists.castor-project.org"
moz-do-not-send="true">castor-users@lists.castor-project.org</a>
<<a
href="mailto:castor-users@lists.castor-project.org"
moz-do-not-send="true">castor-users@lists.castor-project.org</a>><br>
<b>Objet :</b> [Castor-users] CASToR TOF
reconstruction</span><span lang="EN-GB">
</span></p>
<div>
<p class="x_xmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-left:70.8pt">
<span lang="EN-GB"> </span></p>
</div>
</div>
<div>
<div>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">Dear CASToR developers and users,</span><span
lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">I have a question regarding an issue
with CASToR TOF reconstruction.</span><span
lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">I will give a brief background of the
issue: I have modelled the G.E. Discovery MI (DMI)
PET/CT with GATE and simulated a PET acquisition
with the NEMA IQ phantom. I have converted the
data to the CASToR list-mode format and so far,
there are generally no problems. However, when
including TOF in the data file I get an increased
signal in the reconstructed image in places where
I do not expect, e.g., in the lung insertion, but
also a quite reduced signal in the spheres. </span><span
lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">The TOF information for each event
that I write to the binary file I simply take the
arrival time difference between crystal1 and
crystal2, i.e., time1-time2 and then multiply the
difference by 1e+12 to get the delta time in ps. I
then save the crystals in the binary file as
Crystal ID1 (c1) corresponding to GATE crystal1
and Crystal ID2 (c2) corresponding to GATE
crystal2 (since it is mentioned in the general
documentation that the TOF delta time is positive
when the emission occurs closer to c2.) In the
header file I set the TOF resolution to 380 ps and
the TOF measurement range to 4900 ps. I decided to
only write the true coincidences in the binary
file (together with attenuation, normalization,
and the inclusion of a span of 2 for indirect
slices for segment 0) so that I could efficiently
look at the effect of TOF without having to bother
with random- and scatter correction.
</span><span lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">If I then reconstruct the data, I
notice an increased signal in the insertion
compartment, as well as a notable reduction in
signal between some of the spheres (especially
visible between the largest spheres), as opposed
to if I reconstruct the data using the
<i>-ignore-TOF </i>option (or without including
TOF information in neither the binary- nor the
header file.) If I reconstruct the same data but
increase the TOF resolution to, e.g., 700 ps, the
signal in the insertion compartment is reduced and
the reduced signal between spheres are no longer
present. (I also tested using the GATERootToCastor
converter with the TOF resolution to 380 ps
yielding similar results.)</span><span
lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">I have attached images showing a
slice of the three examples that I mentioned (TOF
included with 380 ps TOF resolution, TOF included
with 700 ps TOF resolution, and with the <i>-ignore-TOF
</i>option used.) I have also included profiles
through the same slices passing through two of the
spheres and the insertion compartment.</span><span
lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">Intuitively, this seems to yield
erroneous results (with 380 ps TOF resolution),
but I cannot seem to understand why this effect
occurs. I was hoping someone could help me
understand what the issue might be, if I have
missed something, or whether I am on the wrong
track and have misunderstood the
<i>“TOF-induced”</i> results.</span><span
lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">I hope to hear from you.</span><span
lang="EN-GB"></span></p>
<p class="x_xxmsonormal" style="margin: 0cm 0cm
0.0001pt; font-size: 12pt; font-family: "Times
New Roman", serif;margin: 0cm 0cm 0.0001pt;
font-size: 12pt; font-family: "Times New
Roman", serif;margin-right:0cm;
margin-bottom:8.0pt; margin-left:70.8pt;
line-height:105%">
<span style="font-size:11.0pt; line-height:105%;
font-family:"Calibri",sans-serif"
lang="EN-GB">Best regards,<br>
<i>Philip</i></span><span lang="EN-GB"></span></p>
</div>
</div>
</div>
</div>
</div>
</div>
<br>
<fieldset class="mimeAttachmentHeader"></fieldset>
<pre class="moz-quote-pre" wrap="">_______________________________________________
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<pre class="moz-signature" cols="72">--
Thibaut MERLIN -- PhD
Docteur en Imagerie Médicale au Laboratoire de Traitement de l'Information Medicale (LaTIM - INSERM UMR 1101)
Institut Brestois de recherche en Bio-Santé (IBRBS)
12 Avenue Foch, 29200 Brest, FRANCE
Tel: 06.75.12.24.90</pre>
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